Facilities

  • Smith Group Laboratory
    • The Smith group has both organic chemistry and biochemistry laboratories, located in MCCourtney Hall on The University of Notre Dame Campus.

    • Group Instrument room
    • Fluorescence Spectrometer
      • The Jobin Yvon Horiba FluoroMax-4 is equipped with a Xenon arc lamp, excitation/emission monochromators, a reference photodiode, and a photomultiplier tube for detection making it ideal for providing fundamental steady-state fluorescent measurements. The instrument also features a 4-position sample changer and MicroMax plate reader for multi-well and solid state fluorescence measurements.

    • Fluorescence Spectrometer
      • The Jobin Yvon Horiba FluoroMax-3 is equipped with a Xenon arc lamp, excitation/emission monochromators, a reference photodiode, and a photomultiplier tube for detection making it ideal for providing fundamental steady-state fluorescent measurements.

    • UV-Vis Spectrometer
      • The Thermo scientific Evolution 201 spectrometer features a double beam setup containing Xenon flash lamps with a dual silicon photodiode detector, allowing it to scan wide ranges of wavelengths (190 to 1100 nm) with high accuracy.

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    • UV-Vis Spectrometer
      • The PerkinElmer Lambda 25 spectrometer features a double beam setup containing both tungsten-halogen (Vis-source) and deuterium (UV-source) lamps with a photodiode detector, allowing it to scan wide ranges of wavelengths (190 to 1100 nm) with high accuracy.

    • Biotage Flash Chromatography System
      • The Biotage Isolera one provides gradient solvent addition at a wide range of flowrates, it is equipped with dual wavelength UV-Vis detector. The Biotage equipped with normal silica phase or reverse phase cartridges allowing purifications from mg to g scale.

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    • Microscopes for cell imaging
      • The Nikon TE2000U microscope combines epi-fluoresence and phase contrast to allow for monitoring of fluorescently tagged structures within a specimen at a high resolution.

    • The Zeiss AxioVert S100TV is an epi-fluorescence inverted microscope useful for live mammalian cell and bacteria imaging.

    • Notre Dame Integrated Imaging Facility – NDIIF
      • The In Vivo section of the NDIIF currently houses both the Kodak In Vivo Multispectral FX and the Xenogen IVIS Lumina. A microCT, which can create 3D tomographic reconstructions of living animals, will join the facility in the near future. The NDIIF is directed by Professor Bradley D. Smith and managed by W. Matthew Leevy.

    • The Kodak In Vivo Multispectral FX combines advanced multispectral fluorescence, luminescence, digital x-ray and radioisotopic imaging for noninvasive in-vivo imaging in a single system.

    • The Xenogen IVIS Lumina is a highly sensitive imaging system that offers the flexibility to image fluorescent and/or bioluminescent reporters both in vivo and in vitro.